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Exercise induces metallothioneins in mouse spinal cord.
Hashimoto K, Hayashi Y, Inuzuka T, Hozumi I. Hashimoto K, et al. Neuroscience. 2009 Sep 29;163(1):244-51. doi: 10.1016/j.neuroscience.2009.05.067. Epub 2009 May 30. Neuroscience. 2009. PMID: 19490933
We here present that regular exercise on a treadmill induces metallothioneins (MTs: MT-1, MT-2, and MT-3) in spinal cords of mice. As MTs are strong scavengers of reactive oxygen species and have some neurotrophic activities, exercise may have some beneficial effects on …
We here present that regular exercise on a treadmill induces metallothioneins (MTs: MT-1, MT-2, and MT-3) in spinal cords of mice. As …
Expression of different metallothionein messenger ribonucleic acids in motor cortex, spinal cord and liver from patients with amyotrophic lateral sclerosis.
Blaauwgeers HG, Anwar Chand M, van den Berg FM, Vianney de Jong JM, Troost D. Blaauwgeers HG, et al. J Neurol Sci. 1996 Oct;142(1-2):39-44. doi: 10.1016/0022-510x(96)00013-5. J Neurol Sci. 1996. PMID: 8902718
In earlier studies of sporadic amyotrophic lateral sclerosis (ALS), a disease of unknown etiology, the amount of metallothioneins (MTs), a group of small (6-7 kDa) metal-binding proteins, appeared higher in liver, kidney and spinal cord from patients than from non-n …
In earlier studies of sporadic amyotrophic lateral sclerosis (ALS), a disease of unknown etiology, the amount of metallothioneins (MTs), a g …
Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes.
Zhang HM, Chen SR, Pan HL. Zhang HM, et al. J Neurophysiol. 2007 Jan;97(1):102-9. doi: 10.1152/jn.00586.2006. Epub 2006 Oct 18. J Neurophysiol. 2007. PMID: 17050831 Free article.
To investigate the mAChR subtypes involved in the inhibitory effect of mAChR agonists on glutamate release, evoked excitatory postsynaptic currents (eEPSCs) were recorded in lamina II neurons using whole cell recordings in rat spinal cord slices. The nonselective mA …
To investigate the mAChR subtypes involved in the inhibitory effect of mAChR agonists on glutamate release, evoked excitatory postsynaptic c …
M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons.
Zhang HM, Li DP, Chen SR, Pan HL. Zhang HM, et al. J Pharmacol Exp Ther. 2005 May;313(2):697-704. doi: 10.1124/jpet.104.079939. Epub 2005 Jan 7. J Pharmacol Exp Ther. 2005. PMID: 15640398
To determine the role of receptor subtypes in the muscarinic agonist-induced synaptic GABA release, spontaneous inhibitory postsynaptic currents (sIPSCs) were recorded in lamina II neurons using whole-cell voltage-clamp recordings in rat spinal cord slices. The musc …
To determine the role of receptor subtypes in the muscarinic agonist-induced synaptic GABA release, spontaneous inhibitory postsynaptic curr …
Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception.
Yoon MH, Park HC, Kim WM, Lee HG, Kim YO, Huang LJ. Yoon MH, et al. Life Sci. 2008 Dec 19;83(25-26):845-50. doi: 10.1016/j.lfs.2008.09.028. Epub 2008 Oct 30. Life Sci. 2008. PMID: 19000700
The antinociceptive effect of melatonin was antagonized by luzindole, 4-P-PDOT, and prazosin in the spinal cord. Intrathecal GR 135531 was ineffective against the formalin-induced flinching response. SIGNIFICANCE: These results suggest that melatonin interacts addit …
The antinociceptive effect of melatonin was antagonized by luzindole, 4-P-PDOT, and prazosin in the spinal cord. Intrathecal G …
The expression of metallothioneins is diminished in the spinal cords of patients with sporadic ALS.
Hozumi I, Yamada M, Uchida Y, Ozawa K, Takahashi H, Inuzuka T. Hozumi I, et al. Amyotroph Lateral Scler. 2008 Oct;9(5):294-8. doi: 10.1080/17482960801934312. Amyotroph Lateral Scler. 2008. PMID: 18608104
We analyzed the expression of MTs using immunohistochemistry on the spinal cords of patients with ALS (n =12) and controls (n =12). The immunoreactivities of both MT-1/2 and MT-3 stained dominantly in glial cells and were decreased in the spinal cords of patients wi …
We analyzed the expression of MTs using immunohistochemistry on the spinal cords of patients with ALS (n =12) and controls (n =12). T …
Metallothionein isoform 3 gene is differentially expressed in corticotropin-producing pituitary adenomas.
Giorgi RR, Correa-Giannella ML, Casarini AP, Machado MC, Bronstein MD, Cescato VA, Giannella-Neto D. Giorgi RR, et al. Neuroendocrinology. 2005;82(3-4):208-14. doi: 10.1159/000092521. Epub 2006 Apr 3. Neuroendocrinology. 2005. PMID: 16601360
In order to search for candidate genes related to pituitary adenoma aggressiveness, the present investigation was intended to compare the mRNA expression profile from a pool of four nonfunctional pituitary adenomas (NFPA) with a spinal cord metastasis of a nonfuncti …
In order to search for candidate genes related to pituitary adenoma aggressiveness, the present investigation was intended to compare the mR …
Melatonin inhibits outward delayed rectifier potassium currents in hippocampal CA1 pyramidal neuron via intracellular indole-related domains.
Hou SW, Zheng P, Sun FY. Hou SW, et al. J Pineal Res. 2004 May;36(4):242-9. doi: 10.1111/j.1600-079X.2004.00123.x. J Pineal Res. 2004. PMID: 15066048
Neither luzindole, an MT1/MT2 receptor antagonist, nor prazosin, an MT3 receptor antagonist, blocked melatonin-induced current reduction. ...
Neither luzindole, an MT1/MT2 receptor antagonist, nor prazosin, an MT3 receptor antagonist, blocked melatonin-induced current reduct …